ribosome – Communicable Diseases Research

Epigenetic perspectives of COVID-19: Virus infection to disease progression and therapeutic control

Research article

Published on 2022-12-012022-10-05
Journal: Biochimica et biophysica acta. Molecular basis of
[Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제,

The Translational Landscape of SARS-CoV-2-infected Cells Reveals Suppression of Innate Immune Genes

SARS-CoV-2에 감염된 세포의 번역 환경은 선천 면역 유전자의 억제를 나타냅니다

Article

Published on 2022-06-282022-09-11
Journal: mBio
[Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단,

[키워드] abundantly expressed acute respiratory syndrome acute respiratory syndrome coronavirus Air-liquid interface airway Cell cell cultures cell line cells cellular cellular mRNAs chemokine ciliated ciliated cell coding coronavirus cytokine downregulation event help highlight host mRNA host response host responses immune immune response immune responses infected cells Inflammatory Innate innate immune innate immune response Interaction interferon-stimulated genes involved landscape mechanism mediators modulate mRNA mRNA translation mRNAs notable primary cells programmed frameshifting regulated respiratory ribo-seq ribosomal frameshifting ribosome ribosome profiling ribosomes RNAs SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2-infected cell SARS-CoV-2-infected cells sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 suppression therapeutic therapeutic intervention These data transcriptional Transcriptional upregulation translated translation translation initiation translational translational repression unique upregulation Viral viral mRNA viral mRNAs virus virus replication virus-host interaction.
[DOI] 10.1128/mbio.00815-22 PMC 바로가기 [Article Type] Article

Identification of Diagnostic Gene Markers and Immune Infiltration in Systemic Lupus

전신성 루푸스에서 진단 유전자 마커 및 면역 침윤의 식별

Article

Published on 2022-05-102022-09-11
Journal: Computational and Mathematical Methods in Medicine
[Category] MERS, 바이오마커, 치료기술,

[키워드] Activation advancement analysis Analysis analyzed Atypical autoantibodies autoantibody Autoantigens Autoimmune disease B cells bioinformatics Biomarker Central nervous system characteristic clinical manifestation clinical manifestations Clinical practice coexpressed coexpression network complexes control group coronavirus coronavirus disease correlation COVID-19 current DEGs determine Diagnosis diagnostic differentially expressed gene Differentially expressed genes disease downloaded downregulated Endocrine endocrine system enrichment analysis etiology evaluate expression data Factors fraction functional gene expression profile Genes Genetic GEO database healthy control healthy controls help heterogeneous highest hub genes human body identification identify Immune cell immune cells Immune complexes immune function Infection Interaction joints KEGG kidney leukemia Lupus lupus erythematosus miRNA multiple organs Participation Pathogenesis pathway Pathways Patient patients performed Population Potential biomarker potential biomarkers PPI PPI network protein-protein interaction receiver operating characteristic recognize regulatory network Research resulting ribosome ROC ROC Curve RPL19 RPS17 RPS19 RPS7 selected skin SLE SLE patient SLE patients Symptom systemic systemic lupus erythematosus T cell T cells the disease the healthy transcription factor Treatment turquoise module upregulated variety virus was selected was used weighted gene coexpression network analysis WGCNA whole blood sample
[DOI] 10.1155/2022/3386999 PMC 바로가기 [Article Type] Article

Correlated sequence signatures are present within the genomic 5’UTR RNA and NSP1 protein in coronaviruses

코로나바이러스의 게놈 5'UTR RNA 및 NSP1 단백질 내에 상관된 서열 서명이 존재합니다

Article

Published on 2022-05-012022-09-11
Journal: RNA (New York, N.Y.)
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

Clinically observed deletions in SARS-CoV-2 Nsp1 affect its stability and ability to inhibit translation

SARS-CoV-2 Nsp1에서 임상적으로 관찰된 결실은 안정성과 번역 억제 능력에 영향을 미칩니다

Article

Published on 2022-05-012022-09-11
Journal: Febs Letters
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

The key features of SARS-CoV-2 leader and NSP1 required for viral escape of NSP1-mediated repression

NSP1 매개 억제의 바이러스 탈출에 필요한 SARS-CoV-2 리더 및 NSP1의 주요 기능

Article

Published on 2022-05-012022-09-11
Journal: RNA (New York, N.Y.)
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

Viral and cellular translation during SARS‐CoV‐2 infection

Review

Published on 2022-04-252023-06-16
Journal: FEBS Open Bio
[Category] COVID19(2023년), MERS, SARS,

[키워드] immune response interferon NSP1‐SL1 ribosome SARS‐CoV‐2 translation
[DOI] 10.1002/2211-5463.13413 PMC 바로가기 [Article Type] Review

Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2

Nsp1-리보솜 복합체를 표적으로 하는 약물은 SARS-CoV-2에 대한 항바이러스 활성을 나타냅니다

Article

Published on 2022-03-242022-09-11
Journal: eLife
[Category] SARS, 치료제,

[키워드] 40S ACE2 antiviral activity appear bind binding affinity binding energy block C-terminal can be used cells complex demonstrated drug Drug administration expressing expression firefly luciferase food form HEK cell help Host host protein immune function in silico in vitro inhibitor inhibitory effect linker Medicine Montelukast MONTELUKAST SODIUM mRNA N-terminal domain non-structural protein nsp1 reduced reporter reporter gene ribosomal subunit ribosome SARS-CoV-2 SARS-COV-2 infection screened sodium sodium hydrate stable complex suppresse Therapeutics translation Vero-E6 cells viral replication viruses viruses.
[DOI] 10.7554/eLife.74877 PMC 바로가기 [Article Type] Article

MERS-CoV nsp1 impairs the cellular metabolic processes by selectively downregulating mRNAs in a novel granules

Research Article

Published on 2022-02-062022-10-28
Journal: Virulence
[Category] COVID-19,

Promising Assays for Examining a Putative Role of Ribosomal Heterogeneity in COVID-19 Susceptibility and Severity

Review

Published on 2022-01-282022-10-29
Journal: International Review of Cell and Molecular Biology
[Category] COVID-19,

[키워드] analyses Antiviral treatment arise assays for proteins assays for RNA sequence and structure caused Characteristics characterized clinical sample clinical setting component concurrent COVID-19 COVID-19 disease Critical detect droplet Efficacy element environmental cues Examining generate heterogeneity Host host susceptibility identify include Infection Messenger RNA modifications mRNA Nanopore organism post-translational modification protocol responses ribosomal heterogeneity ribosomal protein ribosomal proteins ribosomal RNA ribosomal RNAs ribosome ribosomes RNA genome RNA sequencing role rRNA rRNAs SARS-CoV-2 SARS-CoV-2 coronavirus selected sequence Sequencing severity of symptoms Side effect Single Cell Statistical power structural variations structures substrate Symptoms the disease the SARS-CoV-2 transcript translate translation translation machinery translational Transmissibility unique vaccine immunogenicity vaccine response variant viral infectivity
[DOI] 10.3390/life12020203 PMC 바로가기 [Article Type] Review